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Minerva Pediatrica 2020 June;72(3):145-8

DOI: 10.23736/S0026-4946.16.04472-8

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Epstein Barr virus induces HERV-K and HERV-W expression in pediatrics liver transplant recipients?

Massimiliano BERGALLO 1, 2 , Michele PINON 3, Ilaria GALLIANO 1, 2, Paola MONTANARI 1, 2, Valentina DAPRÀ 2, Stefano GAMBARINO 2, Pier L. CALVO 3

1 Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Turin, Italy; 2 Laboratory of Citoimmunodiagnostics, Città della Salute e della Scienza, Regina Margherita Children’s Hospital, Turin, Italy; 3 Unit of Pediatric Gastroenterology and Hepatology, Molinette Hospital, Città della Salute e della Scienza, University of Turin, Turin, Italy



BACKGROUND: Human endogenous retrovirus (HER Vs) constitute approximately 8% of the human genome. Induction of HER V transcription is possible under certain circumstances, and may have a possible role in some pathological conditions. Aim of the present study was to verify whether HER V-W and K activation by Epstein Barr Virus (EBV) might occur also in vivo, during EBV infection, in pediatric liver transplant recipients.
METHODS: A total of 35 pediatric liver transplant (LT) patients who received LT at the University Hospital City of Science and Health of Turin, Regina Margherita Children’s Hospital were included. The samples were grouped in EBV negative and positive.
RESULTS: We found that HER V-K, and HER V-W expression levels showed no differences between the two groups (P=0.533 HERV-W and P=0.6017 HERV-K). There was not was a significant difference P=0.1894 and 0.1705 for HERV-W and -K respectively when we compared transplant recipients’ group with high EBV viral load vs. others transplant recipients.
CONCLUSIONS: Our data suggest that EBV does not facilitate in-vivo HERV activation.


KEY WORDS: Epstein Barr virus infections; Transplant recipients; Liver; Pediatrics

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