Home > Journals > Minerva Ortopedica e Traumatologica > Past Issues > Minerva Ortopedica e Traumatologica 2005 August;56(4) > Minerva Ortopedica e Traumatologica 2005 August;56(4):199-207

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

UPDATES ON HIP ARTHROPLASTY  102nd CONGRESS OF THE PIEMONTESE-LIGURIAN-LOMBARD SOCIETY OF ORTHOPEDICS AND TRAUMATOLOGY (S.P.L.L.O.T.) - Brescia September 9-10, 2005
NEW TECHNOLOGIES, MODERN INSTRUMENTARIUM IN ARTHROPLASTIC SURGERY
 

Minerva Ortopedica e Traumatologica 2005 August;56(4):199-207

Copyright © 2005 EDIZIONI MINERVA MEDICA

language: Italian

Periprosthetic osteolysis. Biological or mechanical problem?

Rossi P. 1, Marmotti A. 2, Castoldi F. 1, Rossi R. 1

1 Dipartimento di Ortopedia-Traumatologia e Medicina del Lavoro Università degli Studi di Torino Ospedale Mauriziano Umberto I, Torino 2 UOA Ortopedia e Traumatologia Universitaria Ospedale Mauriziano Umberto I, Torino


PDF


Periprosthetic osteolysis is the dominant long term complication of total hip replacement and is the major cause of loosening of acetabular and femoral components. Mechanical factors and biological agents mutually interact in the genesis of this unique disease. In the microenvironment around total hip replacement prostheses, at the pseudosynovial membrane and at the interface membrane, debris diffusion and cell-particle interaction generate inflammation, but also mechanical factors play a pivotal role, as it is for prosthetic alignement, pressure at the surrounding bone tissue exerted by acetabular and femoral component, micromovement at the implant-to-host interface, pumping of synovial fluid around periprosthetic space during cyclic loading of the joint. Association of these and other elements constitutes the pathogenetic process leading, peculiarly in each individual, to osteolysis and aseptic loosening.

top of page