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MINERVA OFTALMOLOGICA

A Journal on Ophthalmology


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Minerva Oftalmologica 2017 September;59(3):65-8

DOI: 10.23736/S0026-4903.17.01780-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Epigenetics and common ophthalmic diseases

Jennifer A. GALVIN

Eye Surgery Associates LLC, Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA


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The study of ocular diseases and epigenetic dysregulation is an emerging area of research. The knowledge from the epigenetic mechanisms of DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regarding the pathogenesis of ocular diseases will be helpful for improved treatment modalities for our patients. In particular, we focus upon the how epigenetic regulatory mechanisms impact six common ocular diseases: age related macular degeneration, age-related cataract, pterygium, retinoblastoma, and uveal melanoma. Hence, the foundation of this research paves the way for future specific therapeutic targets for vision-preserving and vision-saving disease.


KEY WORDS: Macular degeneration - Cataract - Epigenomics - Pterygium - Retinoblastoma - Uveal melanoma

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Publication History

Issue published online: September 27, 2017
Manuscript accepted: July 28, 2017
Manuscript received: July 26, 2017

Cite this article as

Galvin JA. Epigenetics and common ophthalmic diseases. Minerva Oftalmol 2017;59:65-8. DOI: 10.23736/S0026-4903.17.01780-9

Corresponding author e-mail

jennygalvin@gmail.com