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Minerva Obstetrics and Gynecology 2022 Mar 02
DOI: 10.23736/S2724-606X.21.04951-4
Copyright © 2021 EDIZIONI MINERVA MEDICA
language: English
Predictive value of preoperative complete blood count components on the occurrence of surgical site infection after elective cesarean section
Giovanni SISTI 1, Alexander SABRE 1, Felipe MERCADO 1, Ruchi UPADHYAY 1, Julie JOSEPH 2, Antonio SCHIATTARELLA 2, 3 ✉
1 Department of Obstetrics and Gynecology, New York Health and Hospitals/Lincoln Hospital, Bronx, NY, USA; 2 Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA; 3 Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy
OBJECTIVE: To analyze the predictive value of the preoperative complete blood count components on the occurrence of surgical site infection (SSI) after elective cesarean section.
METHODS: We conducted a retrospective case control study in a tertiary care hospital located in New York City during the period of November 1, 2018, to October 30, 2020. We included patients who developed SSI after elective cesarean section as cases and patients who did not develop SSI as controls. We tested the ability of neutrophil, lymphocyte, platelet, hemoglobin, hematocrit, total white blood cells, neutrophil to lymphocyte ratio, hemoglobin to platelet ratio, platelet to lymphocyte ratio, platelet to neutrophil ratio, platelet to hemoglobin ratio and neutrophil to hemoglobin ratio to identify the occurrence of SSI after cesarean section.
RESULTS: We compared 10 cases and 20 controls. The median lymphocyte and lymphocyte to hemoglobin ratio were statistically significantly higher in cases compared to controls (p-value= 0.049 and 0.04 respectively). A lymphocyte value higher than 1.5 x103/μL was the best cut-off to exclude the occurrence of SSI, with a sensitivity of 95%, a specificity of 50%, a positive predictive value 5.5% and a negative predictive value > 99%. A lymphocyte to hemoglobin ratio higher than 1.13 was the best cut off to exclude the occurrence of SSI, with a sensitivity of 95%, a specificity of 60%, a positive predictive value of 6.8% and a negative predictive value > 99%.
CONCLUSIONS: The preoperative lymphocyte and lymphocyte to hemoglobin ratio should be incorporated into patient counseling and preoperative algorithms to identify patients who will develop SSI. The biological mechanisms involved remain to be investigated and our data should be confirmed by further and larger studies.
KEY WORDS: Complete blood count; Cesarean section; Lymphocyte; Hemoglobin; Prediction; Surgical site infection