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Minerva Obstetrics and Gynecology 2021 Jun 28

DOI: 10.23736/S2724-606X.21.04905-8

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Bone metabolism in pregnancy and lactation

Anna CAPOZZI , Giovanni SCAMBIA, Stefano LELLO

Department of Women and Child Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy


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INTRODUCTION: Different hormonal mechanisms regulate bone metabolism during pregnancy and lactation. In both those periods of life, a fine modulation of calcium metabolism is necessary to meet the needs of foetus and newborn.
METHODS: We review scientific literature on the topic “osteoporosis”, “pregnancy” and “lactation”, evaluating the most relevant data from original articles, reviews and meta-analyses.
EVIDENCE SYNTHESIS: Pregnancy- and lactation-associated bone loss and related fractures rarely occur and, generally, clinicians have to manage it case to case, since there is not a unique guideline. Fortunately, bone mineral density (BMD) usually tends to recover within 12 months after weaning, thus, it could be reasonable waiting of assessing the effective magnitude of bone mass regain before starting any pharmacological treatment.
CONCLUSIONS: Osteoporosis and/or fragility fractures remain uncommon events associated with gestation and/or breastfeeding. The management of bone loss and/or fractures during those periods is generally conservative and a tailored approach is advisable in the absence of any specific recommendation in this field.


KEY WORDS: Pregnancy; Lactation; Osteoporosis; Bone mineral density; Fracture

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