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Minerva Obstetrics and Gynecology 2021 Jun 17

DOI: 10.23736/S2724-606X.21.04813-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

BRCA 1, 2 mutation and earlier menopause. Could BRCA 1, 2 be used as predictor of menopause?

Konstantinos NIKOLETTOS 1 , Christos DAMASKOS 2, 3, Nikolaos GARMPIS 3, 4, Nikos NIKOLETTOS 5

1 Obstetric and Gynecologic Clinic, Thriasio General Hospital, Elefsina, Greece; 2 Renal Transplantation Unit, Laiko General Hospital, Athens, Greece; 3 N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 4 Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 5 Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, Alexandroupolis, Greece


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Many studies have shown that BRCA mutation is not only related to cancer but also to ovarian aging. Studies in both human and mice oocytes have shown that Double-strand breaks (DSBs) accumulate with age. Genome-wide association studies (GWAS) have found 44 genetic loci that are related to variations when a female is about to have menopause. BRCA1 is involved in these 44 loci that are associated with the age of menopause. This review has gathered all results of literature search about the association between BRCA genes and early menopause. The majority of the articles found that women with BRCA mutation have earlier menopause compared to non-carriers. In conclusion, in the near future BRCA1,2 genes could be used as predictive biomarkers of menopause.


KEY WORDS: BRCA 1; BRCA 2; Menopause; Genetic markers; Biomarker

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