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Minerva Obstetrics and Gynecology 2022 April;74(2):117-22

DOI: 10.23736/S2724-606X.21.04727-8


language: English

Anti-Müllerian hormone as a predictor of pregnancy in women under 35 years with unexplained infertility undergoing ICSI: a retrospective study

Hale BAYRAM 1, Ozgur DUNDAR 2, Yaprak DONMEZ CAKİL 3, Elif E. UYAR 4, Mehmet CINCIK 3

1 Institute of Graduate Studies Clinical Embryology Master Program, Maltepe University, İstanbul, Turkey; 2 Kadıköy Florence Nightingale Hospital Obstetrics and Gynecology Department, İstanbul, Turkey; 3 Department of Histology and Embryology, Faculty of Medicine, Maltepe University, İstanbul, Turkey; 4 Acıbadem Health Group, Altunizade Hospital IVF Center, Acıbadem University, İstanbul, Turkey

BACKGROUND: Anti-Müllerian hormone (AMH) is a well-established marker for the determination of ovarian reserve. However, its role in the prediction of pregnancy is still under debate. In this retrospective study, we aimed to evaluate the relationship of serum AMH levels with pregnancy rates in patients with unexplained infertility undergoing ICSI. Moreover, we compared the predictive value of AMH with that of antral follicle count (AFC).
METHODS: Records of 76 patients under 35 years of age with AMH levels between 1 and 3.5 ng/mL were examined retrospectively. Participants were divided into groups based on their AMH level and age.
RESULTS: AMH levels in women under 30 years were found significantly higher than those in women over 30 years (P=0.033). Fifty-seven of 76 patients (75%) were pregnant. Age did not have a significant effect on the pregnancy rates in the selected study group (P=0.252). On the other hand, despite the poor predictive accuracy, serum AMH was shown to have a predictive value with a cut-off point of 1.95 ng/mL. Logistic regression tests demonstrated a higher pregnancy rate (3.396 fold) with an AMH level 1.95 or above. There was no significant relationship between AFC and pregnancy.
CONCLUSIONS: AMH might have a role in the prediction of pregnancy after ICSI in patients under 35 years with unexplained infertility.

KEY WORDS: Infertility; Intracytoplasmic sperm injections; Pregnancy; Fertilization; Anti-Mullerian hormone

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