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REVIEW  UPDATE IN LATE FETAL GROWTH RESTRICTION 

Minerva Obstetrics and Gynecology 2021 August;73(4):471-81

DOI: 10.23736/S2724-606X.21.04823-5

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Postnatal persistence of cardiac remodeling and dysfunction in late fetal growth restriction

Fatima CRISPI 1, Francesca CROVETTO 1 , Mérida RODRIGUEZ-LÓPEZ 1, 2, Álvaro SEPÚLVEDA-MARTINEZ 1, 3, Jezid MIRANDA 1, 4, Eduard GRATACÓS 1

1 Barcelona Center for Maternal-Fetal and Neonatal Medicine (BCNatal), Center for Biomedical Research on Rare Diseases (CIBER-ER), Instituto Clínic de Ginecología, Obstetricia y Neonatología (ICGON), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic and Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain; 2 Pontificia Universidad Javeriana seccional Cali, Cali, Colombia; 3 Unit of Fetal Medicine, Department of Obstetrics and Gynecology, Hospital Clínico de la Universidad de Chile, Santiago de Chile, Chile; 4 Grupo de Investigación en Cuidado Intensivo (GRICIO), Department of Obstetrics and Gynecology, Universidad de Cartagena, Cartagena, Colombia



Fetal growth restriction is one of the most common obstetric complications, affecting 7-10% of all pregnancies. Affected fetuses are exposed to an adverse environment in utero during a critical time of development and may face long-term health consequences such as increased cardiovascular risk in adulthood. Growth restricted fetuses develop remodeled hearts with signs of systolic and diastolic dysfunction. Cardiac adaptations are more evident in early severe cases, but also present in late onset fetal growth restriction. Cardiovascular remodeling persists into postnatal life, from the neonatal period to adolescence, encompassing an increased susceptibility to adult disease. In this review, we summarize the current evidence on cardiovascular programming associated to fetal growth restriction, its postnatal consequences and potential strategies to reduce their cardiovascular risk.


KEY WORDS: Fetal growth retardation; Infant, small for gestational age; Fetal development; Prenatal care; Cardiovascular diseases; Echocardiography

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