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REVIEW  ENDOMETRIOSIS: CURRENT KNOWLEDGE FROM LAB TO CLINIC 

Minerva Obstetrics and Gynecology 2021 June;73(3):333-40

DOI: 10.23736/S2724-606X.21.04711-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Safety of in-vitro fertilization in women with endometriosis

Laura BENAGLIA 1 , Laura MENSI 1, 2, Luca DI GESARO 1, 2, Edgardo SOMIGLIANA 1, 2

1 Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; 2 University of Milan, Milan, Italy



Management of women with endometriosis in general is complex. It requires a multidisciplinary and tailored approach. The time of in-vitro fertilization (IVF) may be particularly complicated because women with the disease face peculiar additional risks. In particular, oocytes retrieval may be more difficult and women with endometriomas are exposed to a low but consistent risk of infection and ovarian abscess development. There are also concerns regarding progression of deep invasive peritoneal lesions and misdiagnosis of an occult early ovarian cancer. However, evidence on these latter points is more controversial. Taken together, this body evidence is generally reassuring and does not justify prophylactic surgery prior to IVF to shrink these risks. However, given the uncertainties, women with endometriosis must be informed in depth of these peculiar additional risks.


KEY WORDS: Endometriosis; Fertilization in vitro; Infections

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