Home > Journals > Minerva Obstetrics and Gynecology > Past Issues > Minerva Ginecologica 2019 August;71(4):263-71 > Minerva Ginecologica 2019 August;71(4):298-305



Publishing options
To subscribe
Submit an article
Recommend to your librarian


Publication history
Cite this article as



Minerva Ginecologica 2019 August;71(4):298-305

DOI: 10.23736/S0026-4784.19.04387-9


language: English

Fertility preservation in female cancer patients: current knowledge and future perspectives

Sebastian FINDEKLEE 1 , Julia C. RADOSA 1, Zoltan TAKACS 1, Amr HAMZA 1, Romina SIMA 2, Erich SOLOMAYER 1, Panagiotis SKLAVOUNOS 1

1 Department of Gynecology, Obstetrics, and Reproductive Medicine, University Hospital of Saarland, Homburg, Germany; 2 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

INTRODUCTION: Protecting fertility in the presence of cancer has become highly significant, as the desire to give birth to a child is increasingly postponed to later in life, and long-term survival with cancer has increased. A variety of fertility-preserving methods have been developed.
EVIDENCE ACQUISITION: To find them, we performed a literature search in Medline using the key words “female fertility preservation in cancer” in December 2017. A total of 2381 different publications were found.
EVIDENCE SYNTHESIS: After screening the abstracts 78 publications in English, French, or German language had been assessed as relevant (17 dealing with medical approaches, six with surgical approaches, 15 with oocyte cryopreservation, 11 with ovarian tissue cryopreservation and 29 were review articles). In general, there are medical (non-surgical) and surgical approaches. Medical approaches comprise administration of GnRH-analogues during gonad toxic oncologic treatment, and cryopreservation of oocytes after ovarian stimulation. Surgical approaches comprise traditional methods of organ-saving surgery and ovarian transposition outside of the radiation portal as well as ovary cryopreservation as standard.
CONCLUSIONS: It is important to inquire about a prospective desire to have children with premenopausal women with cancer and comprehensively explain the fertility conserving methods available. Every premenopausal woman with cancer should be counseled about the methods of fertility protection currently available at a multiprofessional center.

KEY WORDS: Fertility preservation; Neoplasms; Cryopreservation; Cancer survivors

top of page