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ORIGINAL ARTICLES
Minerva Ginecologica 2014 December;66(6):535-42
Copyright © 2014 EDIZIONI MINERVA MEDICA
language: English
Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome
Ademoglu E. 1, Berberoglu Z. 1, Carlioglu A. 2, Dellal F. D. 1, Gorar S. 1, Alphan Z. 1, Uysal S. 3, Karakurt F. 2 ✉
1 Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey; 2 Department of Endocrinology and Metabolism, Turgut Ozal University Faculty of Medicine, Ankara, Turkey; 3 Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey
AIM: The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls.
METHODS: Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m2, N.=36) or overweight/obese (BMI 25-29.9 kg/m2 and ≥30 kg/m2, respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured.
RESULTS: Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (P<0.001). Fasting insulin (P<0.05) and homeostasis model assessment index (P<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (P<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (β-coefficient =0.336, P<0.01), and triglyceride (β-coefficient =0.298, P<0.05).
CONCLUSION: Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear.