THERAPEUTICAL NOTES   

Minerva Ginecologica 2001 April;53(2):141-6

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: Italian

Effect of estriol treatment per vaginam before Burch culposuspension

Palomba S., Napolitano V., Sammartino A., Di Spiezio Sardo A., Vassallo M., Mandato V., Ruoto M., Acunzo G., Votino C., Nappi C.

Background. To assess the effect of estriol treatment per vaginam before Burch culposuspension in postmenopausal women with stress urinary incontinence (IUS).
Methods. Design: prospective randomised study. Setting: Department of Gynaecology, Obstetrics and Physiopathology of Human Reproduction‹Medical School‹University of Naples ''Federico II''. Patients: twenty women in postmenopause at least from five years with a urogenital symptomatology due to IUS. Interventions: women were randomised into one of two groups (treated or control) and they were submitted to an evaluation of vulva and vagina trophism. All the women were submitted to a urodynamic examination and to a transvaginal ultrasonography with evaluation of pubis-bladder neck distance, bladder and proximal urethra position, before treatment, one week before the operation and after six months from the same operation. Evaluations: subjective symptomatology and urodynamic parameters between treated and control groups before and after operation.
Results. After 12 weeks of treatment, a significant improvement of subjective symptomatology and a not significant improvement of all the urodynamic parameters in the treated group in comparison with the control group have been demonstrated, while any anatomic alteration compared with the basal hasn't been observed. After six months from the operation in all the women a significant reduction of subjective quantity of urine lost after a strain has been demonstrated and significant variations of urodynamic parameters without significant differences between treated group and control group were also observed.
Conclusions. The estriol treatment per vaginam is not so effective on the result of Burch culposuspension in postmenopausal women with IUS.