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CASE REPORT   

Minerva Medicolegale 2017 June;137(2):52-5

DOI: 10.23736/S0026-4849.17.01765-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

A fatal case of intoxication after an unsuspected combined intake of verapamil and atenolol

Gian L. MARELLA 1, Valeria OTTAVIANO 2, Carmelo FURNARI 2, Silvestro MAURIELLO 2, Luigi T. MARSELLA 2

1 Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy


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Calcium channel blockers (CCBs) and β-blockers are used, combined or individually, in the treatment of hypertension, angina pectoris, cardiac arrhythmias, and other disorders. However, cardiogenic shock has been reported as a rare complication associated with the combination of verapamil and β-blockers that can be resolved by medical intervention. We describe the case of a 35-year-old woman who developed a fatal cardiogenic shock after an unintentional overdose of verapamil (calcium channel blocker) and atenolol (β blocker) that was discovered only after autopsy and toxicological analyses.


KEY WORDS: Verapamil - Atenolol - Intoxication - Cardiogenic shock - Forensic toxicology

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