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Review Article   

Minerva Medica 2022 Mar 22

DOI: 10.23736/S0026-4806.22.08077-6


language: English

COVID-19 and the enteric system: rapidly propagating issues

Giovanni C. ACTIS 1, Rinaldo PELLICANO 2, Sharmila FAGOONEE 3, Davide G. RIBALDONE 4

1 The Medical Center Practice Office, Turin, Italy; 2 Unit of Gastroenterology, Città della Salute e della Scienza di Torino-Molinette-SGAS Hospitals, Turin, Italy; 3 Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Turin, Italy; 4 Department of Medical Sciences, Division of Gastroenterology, University of Turin, Turin, Italy


The newly described SARS-CoV-2 respiratory virus is now righteously presenting as an ominous threat, based on the speed with which it originated a zoonosis from bats; advancing at a similar rate, the virus has placed mankind before a pandemic, with an infection toll of some 431 million, and a lethality of 5,9 million (as of 25 February 2022). The size of the harm that this agent can unleash against us is appallingly wide, from brain ischemia to foot chilblain, passing by heart massive infarction. Designing a possible response, we reappraised the well-known equation depression-inflammation, and tested the hypothesis that an upgraded ease-of-mind might help reduce the host’s hospitality towards SARS-CoV-2. With time passing, it becomes increasingly evident that the virus shall tend to progressively occupy spaces, replacing pandemics with an apparently calm endemicity. This will have to be avoided, and surveillance of society on psychological terms will be one tenet. Needless to say, the role of the enteric tract in these issues is growing higher, and it will be narrated to seal the matters with the last (not the least) touch of glue.

KEY WORDS: Severe acute respiratory syndrome coronavirus 2; Poly I-C; Poly ICLC; coronavirus-2019; SARS-CoV-2

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