Home > Journals > Minerva Medica > Past Issues > Articles online first > Minerva Medica 2021 Sep 20



To subscribe PROMO
Submit an article
Recommend to your librarian


Publication history
Cite this article as



Minerva Medica 2021 Sep 20

DOI: 10.23736/S0026-4806.21.07776-4


language: English

Prevention of work-related stress, fatigue, loss of cognitive function, attention and recovery of stamina with Robuvit® in professionals with increased oxidative stress

Gianni BELCARO 1 , Maria R. CESARONE 1, Aristide SAGGINO 2, Mark DUGALL 1, Shu HU 1, Claudia SCIPIONE 1, Valeria SCIPIONE 1, Umberto CORNELLI 1, Morio HOSOI 1, Roberto COTELLESE 3, David COX 1, Marcello CORSI 1, Beatrice FERAGALLI 3

1 Irvine3 Labs Institute and OOLEX Research center, Pescara, Italy; 2 Psychology Faculty, D’Annunzio University, Ch - Pe University, Pescara, Italy; 3 RADIOLOGY INSTITUTE Dpt. Sc Med or Biotec, Ch-Pe University, Pescara, Italy


AIM: The aim of this open, pilot supplement registry study was to evaluate the protective, preventive effects of Robuvit® on professional-related fatigue symptoms and on aspects of cognitive functions, professional attitudes and decision-making in healthy nurses under professional stress and with increased oxidative stress.
RESULTS: In total, 40 subjects, aged 30 - 37, completed the 4-week registry study. A control group of 20 subjects used only the standard management (SM) and one group of 20 subjects took 300 mg Robuvit®. Safety and tolerability of Robuvit® were optimal. The two registry groups were comparable at inclusion. The overall scores of the real daily life & tasks questionnaire after 4 weeks were significantly higher in the Robuvit® group (p<0.05) as compared to controls. It increased from 4.3±0.4 at baseline to 6.78±0.8 after 4 weeks of Robuvit® intake and from 4.2±0.5 to 5.12±1.0 in the control group. The supplementation significantly improved the objective perception of fatigue in comparison with controls (p<0.05). A practical professional score evaluation provided an indication of professional attitude and stamina, in difficult, stressful working conditions under continuous pressure. The results showed that after 4-week supplementation all assessed parameters improved significantly and the difference with controls was statistically significant (p<0.05). Furthermore,oxidative stress as plasma free radicals decreased significant in the Robuvit® group (p<0.05) but not in the control group.
CONCLUSIONS: Robuvit® supplementation appears to improve most symptoms related to work-induced fatigue, stress and cognitive function and supports stamina. Further evaluations need to be planned according to the concept of this pilot registry in a field that requires more attention.

KEY WORDS: Fatigue; Professional stress; Stamina; Robuvit; Standardized supplements; Oxidative stress; Burnout

top of page