Home > Journals > Minerva Medica > Past Issues > Articles online first > Minerva Medica 2021 Mar 12

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

Minerva Medica 2021 Mar 12

DOI: 10.23736/S0026-4806.21.07448-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Cognitive reserve and Alzheimer’s biological continuum: clues for prediction and prevention of dementia

Alessandro MARTORANA 1 , Martina ASSOGNA 1, 2, Vincenzo DE LUCIA 1, Caterina MOTTA 2, Chiara G. BONOMI 1, Francesca BERNOCCHI 1, Martina G. DI DONNA 1, Giacomo KOCH 2

1 Memory Clinic, Policlinico Tor Vergata, University of Rome Tor Vergata, Rome, Italy; 2 Non Invasive Brain Stimulation Unit, IRCCS Santa Lucia, Rome, Italy


PDF


Cognitive reserve is originally an epidemiological concept that encompasses individual abilities to cope with changes. It is considered the result of a balance between processes of cellular damage and repair, and its description raised much interest in predicting and preventing cognitive decline in aging and Alzheimer’s disease (AD). Here we discuss the concept of cognitive reserve in light of the recent definition of AD as a biological continuum and suggest that the protection of cognitive reserve may result from efficient synaptic plasticity mechanisms. Despite pathological changes of AD appearing very early during life, long before the onset of cognitive symptoms, different variables act together to keep repair mechanisms effective guaranteeing successful aging as long as environmental enrichment is maintained.


KEY WORDS: Alzheimer’s disease; Cognitive reserve; CSF; Amyloid Beta; Tau; Neuronal repair

top of page