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Minerva Medica 2020 Mar 12
DOI: 10.23736/S0026-4806.20.06444-7
Copyright © 2020 EDIZIONI MINERVA MEDICA
language: English
The relationship between TEM8 and early diagnosis and prognosis of lung cancer
Minghua SUN 1, Hua LI 2, Jing LIU 3, Lirong NING 1, Dongjie ZHAO 1, Shiyong LIU 4 ✉
1 Department of Oncology, Zhongmeng Hospital, Zhalantun, China; 2 Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China; 3 Department of Imaging, Zhongmeng Hospital, Zhalantun, China; 4 Department of Traditional Chinese Medicine, Zhongmeng Hospital, Zhalantun, China
BACKGROUND: To explore the TEM8 expression in patients with lung cancer and its relationship with clinical pathology and prognosis, and to analyze the diagnostic value of TEM8.
METHODS: A total of 204 patients with lung cancer diagnosed and treated in Zhongmeng Hospital Zhalantun and the First Affiliated Hospital of Jinzhou Medical University from March 2013 to February 2016 were enrolled in the study group, and 203 healthy subjects in the control group. qRT-PCR technique was applied to detect the TEM8 expression. Combined with clinical information, the diagnostic value of TEM8 for lung cancer and the correlation of clinical characteristics of TEM8 were analyzed. The 3-year survival curves of patients with low and high TEM8 expressions were compared.
RESULTS: The expression in the study group was significantly higher than that in the control group (p<0.05). When the cut-off value was 1.125, the sensitivity, specificity and AUC of TEM8 in the diagnosis of lung cancer were 50.00%, 98.00% and 0.726 respectively. The TEM8 expression also differs when in smoking, lymphatic metastasis, TNM stage, differentiation degree and pleural invasion classification (p< 0.050). 132 patients were included in the survival group and 72 patients were included in the death group. There was a difference between the two groups in the effect of TEM8 on the prognosis (p<0.001).
CONCLUSIONS: TEM8 showed high expression in the study group. TEM8 had good diagnostic efficacy and was expected to be an excellent indicator for early clinical diagnosis and prognosis of lung cancer.
KEY WORDS: Lung cancer; Diagnosis; Prognosis; TEM8; Clinical characteristics