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MINERVA MEDICA

A Journal on Internal Medicine


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Minerva Medica 2017 Nov 07

DOI: 10.23736/S0026-4806.17.05447-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The relationship between the vitamin serum 25(OH)D and the B12 concentrations in obese women

Nikola CURIC 1, Branislava ILINCIC 1, Natasa MILIC 2, Velibor CABARKAPA 1, Stanislava NIKOLIC 1, Milica MEDIC-STOJANOSKA 3, Rinaldo PELLICANO 4, Ludovico ABENAVOLI 3, 5

1 University of Novi Sad, Faculty of Medicine, Clinical Centre of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia; 2 University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia; 3 University of Novi Sad, Faculty of Medicine, Clinical Centre of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Novi Sad, Serbia; 4 Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy; 5 Department of Health Sciences, University “Magna Græcia”, Catanzaro, Italy


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BACKGROUND: In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12), may be the result of different pathophysiological mechanisms, but the possible association between them has not yet been defined. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 levels in middle aged women.
METHODS: In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis. Vitamin D and VB12 status was assessed by laboratory measurement [serum 25(OH)D levels by electrochemiluminescent immunoassay; VB12 by chemiluminescent microparticle immunoassay].
RESULTS: Obese women were mostly VD deficient [25(OH)D below 50 nmol/L; 40/50, 80%]. Also, among obese we observed presence of VB12 deficiency [VB12 below 148 pmol/L; 13/50, 26%) and marginal depletion of VB12 level (marginal VB12 status 148-221 pmol/L; 20/50, 40%). All anthropometric indicators of obesity, ECV and TBW were significantly associated with both, 25(OH)D and VB12 (p<0.001) levels. In univariate regression analysis serum level of 25(OH)D was significantly associated with VB12 levels (R2=0.170, p<0.001). In regression models, 25(OH)D was significantly associated with VB12 level, independently of fat mass and extracellular fluid volume.
CONCLUSIONS: Obesity may negatively affect VB12 level, indirectly, by reducing 25(OH)D level in middle aged women.


KEY WORDS: Vitamin D - Vitamin B12 - Micronutrient - Deficinecy - Fat mass

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Publication History

Article first published online: November 7, 2017
Manuscript accepted: November 6, 2017
Manuscript received: October 2, 2017

Cite this article as

Curic N, Ilincic B, Milic N, Cabarkapa V, Nikolic S, Medic-Stojanoska M, et al. The relationship between the vitamin serum 25(OH)D and the B12 concentrations in obese women. Minerva Med 2017 Nov 07. DOI: 10.23736/S0026-4806.17.05447-7

Corresponding author e-mail

l.abenavoli@unicz.it