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ORIGINAL ARTICLE   

Minerva Medica 2020 October;111(5):491-7

DOI: 10.23736/S0026-4806.20.06621-5

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Detection of immunoglobulin indexes by immunoturbidimetry: patients with chronic hepatitis B

Zhiheng LI 1, Yamei YANG 2

1 Laboratory Department, The Third People’s Hospital of Baoji, Baoji, China; 2 Laboratory Department, Baoji People’s Hospital, China



BACKGROUND: The objective of this study was to explore the clinical effect of immunoglobulin test in patients with chronic hepatitis B.
METHODS: Fifty patients with chronic hepatitis B, 50 patients with liver failure and 50 patients with cirrhosis were selected from the Third People’s Hospital of Baoji as experimental groups, and 50 healthy people as the control group. The immunoglobulin M (IgM), IgG and IgA levels in serum of the patients were tested by immunoturbidimetry before and after targeted treatment.
RESULTS: Before treatment, the level of Ig in patients with hepatitis B, liver failure and cirrhosis were significantly higher than those in normal people; the level of Ig in patients with hepatitis B were significantly lower than those in patients with liver failure and cirrhosis, and the level of Ig in patients in different groups increased significantly as the disease developed. After treatment, the level of Ig in patients in different groups decreased significantly; patients in the experimental group who had good treatment result had significant decrease of Ig level, while patients in the experimental group who had aggravated disease condition had significant increase of Ig level.
CONCLUSIONS: Detection of serum Ig level in patients with chronic hepatitis B can effectively help determine the condition of patients before and after treatment, so as to formulate appropriate treatment plan.


KEY WORDS: Chronic hepatitis B; Immunoglobulins; Immunoturbidimetry

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