Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2020 August;111(4) > Minerva Medica 2020 August;111(4):330-6

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

ORIGINAL ARTICLE   

Minerva Medica 2020 August;111(4):330-6

DOI: 10.23736/S0026-4806.19.06331-6

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Changing epidemiology of acute liver failure in Italy: a single-center experience over 25 years

Pietro AMOROSO 1 , Salvatore BUONOCORE 1, Gennaro LETTIERI 1, Gaetano PESCE 1, Paola PIERRI 1, Raffaele DE SENA 1, Giuseppe MORELLI 1, Bianca MATTEIS 1, Chiara DELL’ISOLA 1, Valeria DE MARINO 1, Anna R. CICCAGLIONE 2, Rodolfo PUNZI 1, Ciro ESPOSITO 3, Enea SPADA 2

1 Department of Infectious Diseases, D. Cotugno Hospital, Naples, Italy; 2 Department of Infectious Diseases, National Institute of Health, Rome, Italy; 3 Department of Transplants, A. Cardarelli Hospital, Naples, Italy



BACKGROUND: Acute liver failure (ALF) is a rare but often lethal syndrome. In Italy, recent data on its incidence and causes are lacking. We report here the epidemiological analysis of ALF cases observed in Campania, a Southern Italian region, over the last 25 years.
METHODS: Medical records of ALF cases hospitalized from 1992 to 2018 were retrospectively analyzed.
RESULTS: Two hundred ten ALF cases occurred during 1992-2018: 103 (49%) hepatitis B virus (HBV)-related (including 5 cases also infected with Delta virus), 39 (19%) from undetermined cause, 36 (17%) drug-induced, 11 (5%) Wilson’s disease-associated, 8 (4%) hepatitis A virus (HAV)-related and 12 (6%) from other causes. Separate time-periods analysis of data showed a significant progressive decrease in ALF incidence mainly attributable to a decline of HBV and other viruses etiology. Already before 2010, HAV or Delta virus-related cases have no longer been observed. No hepatitis C or E virus-related ALF was detected through the study period. A progressive decrease in frequency of ALF due to undetermined causes or drug was also evident.
CONCLUSIONS: A decrease in ALF incidence and a changing in its etiology were observed in Campania during 1992-2018. Both results were likely mainly due to 1991 introduction of HBV universal vaccination and may be considered generalizable nationwide.


KEY WORDS: Liver failure, acute; Epidemiology; Italy

top of page