REVIEW  MULTIDISCIPLINARY MANAGEMENT OF ENDOMETRIOSIS 

Minerva Medica 2020 February;111(1):21-32

DOI: 10.23736/S0026-4806.19.06358-4

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

The role of survivin in the pathogenesis of endometriosis

Bianca BIANCO ^{1, 2} ✉, Carolina FILIPCHIUK ¹, Denise M. CHRISTOFOLINI ², Caio P. BARBOSA ², Erik MONTAGNA ³

¹ Center of Natural and Human Sciences (CCNH), Universidade Federal do ABC, Santo André, Brazil; ² Department of Collective Health, Discipline of Sexual and Reproductive Health and Populational Genetics, Faculdade de Medicina do ABC/Centro Universitário Saúde ABC, Santo André, Brazil; ³ Postgraduate Program in Health Sciences, Faculdade de Medicina do ABC/Centro Universitário Saúde ABC, Santo André, Brazil

INTRODUCTION: Endometriosis is a common, estrogen-dependent condition, defined as the presence of endometrial-like tissue outside of the uterus, associated with often chronic and inflammatory reaction. The association of endometriosis with cancer is unclear, although endometriosis and cancer present some molecular similarities. Survinin, encoded by the BIRC5 gene, is a protein that controls cell division, inhibits apoptosis and promotes angiogenesis. Here we aimed to summarize and to discuss the main findings of studies that addressed the involvement of survivin in the pathogenesis of endometriosis.
EVIDENCE ACQUISITION: We conducted a comprehensive retrieval from electronic databases, included the MEDLINE, EMBASE, with no restrictions to time span. We used the search terms endometriosis and survivin or BIRC5 and collected all relevant studies to explore the association between endometriosis and surviving expression.
EVIDENCE SYNTHESIS: A total of 21 studies included in the systematic review, comprising sample collected from 1263 women with endometriosis. Results showed the involvement of more than 60 genes and proteins evaluated in eutopic, ectopic, endometrial and ovarian endometriosis, as well as in several gynecological conditions compared to healthy controls.
CONCLUSIONS: The studies provided the basis for the involvement of survivin in the pathogenesis of the disease by several and independent pathways.

KEY WORDS: Endometriosis; Survivin; Apoptosis; Inhibitor of apoptosis proteins