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Minerva Medica 2019 June;110(3):209-15

DOI: 10.23736/S0026-4806.19.05992-5

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Sublingual sufentanil tablet system for postoperative analgesia after gynecological surgery

Yigal LEYKIN 1 , Alessandro LAUDANI 1, Nicola BUSETTO 1, Gabriele CHERSINI 2, Luca F. LORINI 2, Dario BUGADA 2

1 Unit of Anesthesia and Intensive Care, Azienda per l’Assistenza Sanitaria n. 5 - Friuli Occidentale, Pordenone, Italy; 2 Emergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy



BACKGROUND: Gynecological procedures are among the most frequent surgical interventions, and effective postoperative analgesia is associated with improved patient comfort. Despite the efficacy of neuraxial analgesia, limitations and potential complications have led to seek new strategies for pain relief. A novel, pre-programmed, non-invasive, hand-held system (Sufentanil Sublingual Tablet System [SSTS]) displayed good results in the orthopedic setting. However, it has never been applied in gynecological procedures.
METHODS: This retrospective observational case series evaluates receiving SSTS for postoperative analgesia. Data from 42 consecutive patients undergoing open gynecological surgery with Pfannenstiel incision were retrieved from medical charts in two Italian hospitals.
RESULTS: The mean age was 49±11 years, and mean BMI was 24.4±4.6 kg/m2. We reported effective relief on both static and dynamic pain all along the perioperative period, with good effect on patient’s rehabilitation. Postoperative nausea and vomiting is the most common adverse effect, but the incidence was strongly decreased with medical prophylaxis. SSTS was easy to prepare, use and manage by both patients and care providers.
CONCLUSIONS: SSTS may be an interesting option for postoperative analgesia in gynecologic procedures. The efficacy in the management of dynamic pain is an interesting outcome that needs to be compared with the other standards of pain management, such as neuraxial techniques. Rigorous studies are required to give conclusive evidence, but this is the first report, to our knowledge, of SSTS use in open gynecologic procedures. Our preliminary experience encourages the routine application of SSTS in gynecologic surgery and will help designing future randomized controlled trials on the topic.


KEY WORDS: Gynecologic surgical procedures - Sufentanil - Tablets - Analgesia

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