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Minerva Medica 2018 June;109(3):203-10

DOI: 10.23736/S0026-4806.18.05435-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Treatment rate for HCV in the direct-acting antivirals era in HIV co-infected patients: data from an Italian cohort

Gianluca CUOMO , Cinzia PUZZOLANTE, Claudia LAZZARETTI, Giovanni GUARALDI, Vanni BORGHI, Cristina MUSSINI

Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy


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BACKGROUND: New direct antiviral agents (DAA) are now effective in hepatitis C virus (HCV) infection; persons living with human immunodeficiency virus (HIV) (PLWH) were undertreated. Aim of this study was to describe the management of HCV treatment in a HIV/HCV cohort during a 16 years period.
METHODS: An electronic review of all HIV patients with >1 clinic check from the year 2000 was made. Demographic, virologic and treatment data were collected.
RESULTS: From 2000 to 2015 a total of 2352 PLWH were enrolled; 776 (33%) resulted positive at HCV antibodies, and were mostly genotype 1 and 3. 279/579 (48.2%) were treated, and 170 (29.3% of total, 60.9% of treated) obtained a SVR. Treatment rate for HCV had a significant increase in the 2015 (20.6%, P<0.05 when compared with previous years). SVR rate was significantly improved in the 2015 (P<0.05 when compared with each single previous year). At univariate analysis among the different year group there were significant differences in term of HCV RNA positive patients (P<0.001), number of treated (total) and naïve patients (P<0.001 in each of cases), SVR rate (P<0.001), mortality rate (P=0.003). HCV-Ab positive patients with HCV-RNA not detectable (cured) increased during years. At 2015, 50.4% of the HCV-Ab positive patients resulted to be HCV-RNA negative.
CONCLUSIONS: In the DAA’s era a significant increase in the number of treatments was observed. SVR rate was significantly higher. Treatment rate still remains quite low. More than a half of our population of HCV co-infected patients results to be cured for HCV.


KEY WORDS: Hepatitis C - HIV - Antiviral agents

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