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Minerva Medica 2016 August;107(4):259-69

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Single nucleotide polymorphisms of MIR-149 gene rs2292832 contributes to the risk of hepatocellular carcinoma, but not overall cancer: a meta-analysis

Hongjun JIA ¹, Hengwang YU ², Qingzhan LIU ¹ ✉

¹ Department of Radiotherapy, Linyi Peoples’ Hospital, Linyi, China; ² The Sixth Department of Internal Medicine, The People’s Hospital of Linshu, Linshu, China

INTRODUCTION: Single nucleotide polymorphism in miRNAs can alter its expression, thus can lead to the development of cancers. Numerous studies have explored the association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma (HCC) risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result.
EVIDENCE ACQUISITION: Odds ratios (OR) with 95% confidence intervals (CI), calculated by STATA software, was used to determine whether MIR-149 gene rs2292832 polymorphism contributes to the risk of HCC. A comprehensive literature search was conducted on Medline (mainly PubMed), Cochrane Library database, Web of science and the China National Knowledge Internet (CNKI) up to March 22, 2016.
EVIDENCE SYNTHESIS: A total of 19 studies including 8201 cases and 9294 controls were included in this meta-analysis. Four of 20 studies related to the HCC risk. When all the eligible studies were pooled into this meta-analysis, a significant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk.
CONCLUSIONS: Our meta-analysis supports that the MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC from currently available evidence. However, a study with a larger sample size is needed to further evaluate gene-environment interaction on MIR-149 gene rs2292832 polymorphism and HCC risk.