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Minerva Medica 2016 April;107(2):114-22

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Fentanyl citrate sublingual formulation (Vellofent®) for quick BTcP hindering

Patrizia ROMUALDI, Sanzio CANDELETTI

Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Bologna, Italy


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The management of cancer pain presents manifold challenges: even though background pain is adequately controlled, patients frequently experience episodes of acute pain exacerbation known as breakthrough cancer pain (BTcP). The characteristics of BTcP are a rapid onset, a short duration, and a severe intensity. An innovative sublingual fentanyl citrate formulation (Vellofent®) has been developed to target BTcP. The new formulation allows to increase the solubility of fentanyl and to provide optimal oromucosal conditions for rapid drug absorption, thus featuring a shorter time to onset of pain relief (from 6 minutes post-administration).

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