Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2013 April;104(2) > Minerva Medica 2013 April;104(2):131-9

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

  THROMBOSIS 

Minerva Medica 2013 April;104(2):131-9

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

New anticoagulants for the treatment of venous thromboembolism

Prandoni P., Dalla Valle F., Piovella C., Tormene D., Pesavento R.

Department of Cardiothoracic and Vascular Sciences, University of Padua, Padua, Italy


PDF


In recent years, the significant limitations associated with the use of vitamin K antagonists (VKA) have encouraged the development of new agents. Based upon the central roles played by the serine proteases thrombin and Factor Xa in the blood coagulation cascade, direct thrombin inhibitors and direct Factor Xa inhibitors have been developed. These agents, which include the direct thrombin inhibitor dabigatran etexilate and the Factor Xa inhibitors rivaroxaban and idrabiotaparinux are free from many of the limitations of VKAs. According to the results of available phase III randomized clinical trials, both dabigatran and rivaroxaban are effective and safe enough to qualify as ideal oral anticoagulants for the initial and long-term treatment of patients with acute venous thromboembolism (VTE). Rivaroxaban does not require an initial parenteral treatment and can be given in once daily administrations after the first three weeks. Both of them have limitations for the treatment of patients with severe renal failure, and require further investigations in cancer patients and in pregnant patients with VTE. Both of them lack an antidote.

top of page