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A Journal on Internal Medicine

Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Medica 2012 October;103(5):369-76


language: English

Circulating resistin is elevated in patients with non-alcoholic fatty liver disease and is associated with steatosis, portal inflammation, insulin resistance and nonalcoholic steatohepatitis scores

Şenateş E. 1, 2, Çolak Y. 3, Yeşil A. 1, Coşkunpinar E. 4, Şahin Ö. 5, Kahraman Ö. T. 4, Erkalma Şenateş B. 6, Tuncer I. 3

1 Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey; 2 Department of Gastroenterology, Dicle University Medical Faculty, Diyarbakır, Turkey; 3 Department of Gastroenterology, Göztepe Education and Research Hospital, Istanbul, Turkey; 4 Department of Molecular Medicine, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey; 5 Neuromuscular Pathology Unit, Department of Neurology, Istanbul University, Istanbul Medical Faculty, Capa, Istanbul; 6 Deparment of Internal Medicine, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey


AIM:We aimed to investigate the association between serum levels of resistin and the biochemical and histological features of patients with nonalcoholic fatty liver disease (NAFLD) to determine the usefulness of this relationship in the clinical practice.
METHODS:A total of 97 patients with NAFLD and 66 age- and sex-matched healthy controls were recruited. Detailed epidemiological, anthropometric and laboratory data were recorded. Serum levels of resistin were measured with ELISA.
RESULTS: Serum levels of resistin were significantly higher in patients with NAFLD (32.10±10.0 ng/mL and 26.57±13.60 ng/mL, respectively) compared with healthy controls (P=0.003). Serum resistin levels were associated with AST, ALT, HOMA-IR, histological steatosis, portal inflammation and nonalcoholic steatohepatitis (NASH) scores. The serum levels of resistin were significantly higher in patients with definite NASH compared to patients with simple steatosis (29±13 and 20±10 ng/mL, respectively, P=0.03). There was no association between the serum resistin levels and the liver fibrosis stages.
CONCLUSION: Our data suggest that resistin levels are elevated in patients with NAFLD and could discriminate simple steatosis from definite NASH.

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