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Minerva Medica 2010 June;101(3):149-62

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Cell adhesion: implication in tumor progression

Zigler M., Dobroff A. S., Bar-Eli M.

Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA


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Changes in the adhesive properties of neoplastic cells, as well as intracellular signaling mediated by cell surface adhesion molecules, play essential roles in the development and progression of cancer. In this review, we summarize the recent progress in understanding the biology of cell adhesion molecules (CAMs) as well as their clinical significance as prognostic biomarkers or as potential therapeutic targets in a variety of malignancies.

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