REVIEWS  VIRAL DISEASES 

Minerva Medica 2009 December;100(6):447-58

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Therapy of chronic hepatitis B: new goals and new treatments

Mauss S. ✉

Center for HIV and Hepatogastroenterology, Duesseldorf, Germany

Treatment of chronic hepatitis B has shown a rapid development in the last years leading to a shift of treatment strategies from interferon to hepatitis B virus (HBV)-polymerase inhibitors. In particular, treatment with HBV-polymerase inhibitors has changed the indication on how to treat a patient and when to stop therapy. Long-term treatment with HBV-polymerase inhibitors may often be required, even if it raises the possibility of resistance and subsequent treatment failure. This review provides a strategy on how to manage HBV therapy with the currently available treatment options.