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Minerva Medica 2008 June;99(3):289-306


language: Italian

Advanced glycation and lipoxidation end-products amplify inflammation. The role of a healthy diet

Orlando G. 1, Bengmark S. 2

1 Unità di Trapianto dei reni, Ospedale San Salvatore, L’Aquila, Italia 2 Istituto di Epatologia Dipartimento di Epatologia e Chirurgia Università di Londra, Londra, Regno Unito


Increasing evidence suggests that an unhealthy life style is negatively associated with all chronic diseases (CD). Common to most CD is a more or less permanent exaggerated inflammation associated with increased oxidation, strongly associated with metabolic syndrome and also increased deposition in tissues of advanced glycation and lipoxidation end-products (AGE/ALE). It is suggested that all CD patients, including those suffering from genetic disorders or from diseases of obscure etiology, will benefit from measures to control AGE/ALE. It is likely, but yet not proven, that control of intake and cellular production of AGE/ALE is an important ingredient in a healthy lifestyle, and might further improve outcome. An exaggerated inflammation is also observed in patients who suffer from complications of acute diseases: infections, trauma and advanced surgical and medical treatments such as transplantations. Complications and sequelae to these events are significantly more common in elderly and particularly in those with CD. Much supports that the lifestyle of the patients and degree of inflammation before trauma significantly affects outcome. Recently accumulated knowledge about the link between metabolic syndrome and increased deposition of AGE/ALE in the body supports the suggestion that future attempts to minimize accumulation in the body of such substances might significantly reduce both acute and chronic morbidities. However, the research in this field is at the beginning, and most studies remain to be done.

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