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Minerva Medica 2003 October;94(5):341-6

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English

FasL and Bax genes are differentially expressed in acinar epithelium and inflammatory cells of primary Sjögren salivary glands

Badillo-Almaraz I., Avalos-Díaz E., Villalobos-Hurtado R., Herrera-Esparza R.


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Aim. Assess the expression of FasL, Bax, TNFa and IL-6, genes in salivary glands of primary Sjögren patients.
Methods. Twenty minor salivary glands from patients with primary Sjögren syndrome were studied by in situ hybridization with cDNA fluorescent probes. An equal number of control biopsies were included.
Results. Sjögren salivary glands differentially display the inflammatory cytokines and pro-apoptotic mRNAs as follows: mononuclear infiltrating cells exhibited IL-6 and TNFa, whereas the ductal epithelium and acinary cells mainly expressed FasL and Bax. Control biopsies were negative.
Conclusion. Present data suggest that local production of inflammatory cytokines would induce the Fas and Bax pathways committing the ductal epithelium and the acinary cells to apoptosis.

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