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Minerva Ginecologica 2020 May 13

DOI: 10.23736/S0026-4784.20.04564-5


language: English

Behcet’s disease and pregnancy: a review of the literature

Lucia MERLINO 1, Federica DEL PRETE 1 , Benedetta LOBOZZO 1, Roberta PRIORI 2, Maria Grazia PICCIONI 1

1 Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy; 2 Department of Internal Medicine and Medical Specialties, Rheumatology Unit, Sapienza University of Rome, Rome, Italy


INTRODUCTION: Behcet’s disease (BD) is a rare inflammatory, multisystemic, autoimmune disorder with unknown origin. BD is included in vasculitic disorders with a more frequent onset characterized by oral and genital ulcers associated with eye inflammation. However, the clinical manifestations of BD are varied and the most fearful complication is the thrombotic involvement. BD occurs mainly in women of childbearing age, therefore it is important to identify the potential risks of pregnancy on the mother and fetus.
EVIDENCE ACQUISITION: The aim of our review is to identify, through the study of existing literature, the possible consequences of pregnancy on the course of this disease, the potential risks for the mother and fetus in gestation period and in puerperium, in order to identify a correct pregnancy management in patient affected by BD.
EVIDENCE SYNTHESIS: Currently, there are few studies that have analyzed the consequences of the disease on the course of pregnancy and pregnancy on the activity of the pathology. Some authors believe that pregnancy may worsen the symptoms of the disease, while others may even improve the course. Many authors believe that thromboembolic events are the main problems for which focus attention on these patients, both in pregnancy and in puerperium. Different opinions exist about pregnancy complications and neonatal outcomes, although events such as abortion, intrauterine growth restriction and C-section appear to have a higher incidence in BD patients.
CONCLUSIONS: There are no contraindications for the onset of pregnancy in BD patients. In most cases pregnancy can improve the course of the disease. However, in view of the potential adverse events, it is necessary make a careful follow-up of the pregnancy in order to minimise any risks to the mother and fetus.

KEY WORDS: Bechet’s disease; Bechet’s disease in pregnancy; Pregnancy care; Obstetric complications; Neonatal outcomes

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