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A Journal on Obstetrics and Gynecology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index



Minerva Ginecologica 2018 Apr 11

DOI: 10.23736/S0026-4784.18.04230-2


language: English

Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidences

Stefano PALOMBA 1 , Angela FALBO 2, Jessica DAOLIO 2, Francesco A. BATTAGLIA 1, Giovanni B. LA SALA 2, 3

1 Department of Obstetrics & Gynecology, Grande Ospedale Metropolitano "Bianchi, Melacrino - Morelli", Reggio Calabria, Italy; 2 Department of Obstetrics and Gynecology, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy; 3 University of Modena and Reggio Emilia, Reggio Emilia, Italy


Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science. Outcomes were classified in: early pregnancy complications, late pregnancy complications, perinatal complications, offspring health and long-term offspring and maternal health. Even if the exact mechanisms involved are still unclear, women with PCOS have an increased risk of pregnancy-related complications, such as gestational diabetes mellitus (GDM), pregnancy- induced hypertension (PIH), preeclampsia (PE), premature delivery and caesarean section. Moreover, the offspring of women with PCOS are also at increased risk of congenital anomalies and hospitalization in childhood. Further study are needed to study the mechanism underlying pregnancy complications in PCOS and to identify any interventions to reduce the risk of obstetric and neonatal risks in women affected by PCOS and in their offspring.

KEY WORDS: Complications - Obstetrics - Offspring - PCOS - Polycystic ovary syndrome - Pregnancy

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Publication History

Article first published online: April 11, 2018
Manuscript accepted: April 4, 2018
Manuscript received: March 17, 2018

Cite this article as

Palomba S, Falbo A, Daolio J, Battaglia FA, La Sala GB. Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidences. Minerva Ginecol 2018 Apr 11. DOI: 10.23736/S0026-4784.18.04230-2

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