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REVIEW  FERTILITY PRESERVATION IN WOMEN 

Minerva Ginecologica 2018 August;70(4):444-55

DOI: 10.23736/S0026-4784.18.04231-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

From isolation of human ovarian follicles to the artificial ovary: tips and tricks

Maria C. CHITI 1, Jacques DONNEZ 2, Christiani A. AMORIM 1, Marie-Madeleine DOLMANS 1, 3

1 Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; 2 Society for Research into Infertility, Brussels, Belgium; 3 Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels, Belgium


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Cryopreservation and transplantation of ovarian tissue has proved to restore both endocrine and reproductive functions in cancer patients. However, women with a high risk of ovarian involvement cannot undergo ovarian tissue transplantation due to possible recurrence of the disease. Therefore, different teams worldwide are now working on the development of experimental strategies, like the transplantable artificial ovary (TAO), with the noble goal to offer to these patients hope for future conception. This article discusses some essential points for the creation of a TAO and reviews the latest progress made.


KEY WORDS: Ovarian follicle - Artificial organs - Ovary - Fertility preservation

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