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REVIEW  FERTILITY PRESERVATION IN WOMEN 

Minerva Ginecologica 2018 August;70(4):432-5

DOI: 10.23736/S0026-4784.18.04240-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Successful pregnancy in a woman previously suffering from β-thalassemia following transplantation of ovarian tissue cryopreserved before puberty

Sara J. MATTHEWS 1, 2, Helen PICTON 3, Erik ERNST 4, Claus Y. ANDERSEN 5

1 The Portland Hospital for Women and Children, London, UK; 2 Laboratory of Reproductive Biology, Section 5712, University Hospital of Copenhagen, Copenhagen, Denmark; 3 The Division of Reproduction and Early Development, School of Medicine, University of Leeds, Leeds, UK; 4 The Fertility Clinic, Horsens Hospital, Horsens, Denmark; 5 Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark


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Ovarian tissue removed from a 9-year-old girl suffering from thalassemia was kept deep-frozen for 14 years before being transplanted back to the now adult woman. Subsequently, she conceived following IVF treatment and delivered a healthy baby where the oocyte derived from the transplanted tissue. This is the first woman worldwide to have a baby where the ovarian tissue was frozen pre-pubertally and expand the therapeutic options for rare genetic diseases like thalassemia and girls who suffer from childhood cancer.


KEY WORDS: Ovary - Freezing - Fertility preservation - Transplantation - Thalassemia

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