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Minerva Ginecologica 2015 April;67(2):217-23

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

New paradigms in PCOS: impaired glucose tolerance and cardiovascular risk. Clinical approach

Ravn P.

Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark


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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age and is associated with various metabolic risk factors, in addition to chronic anovulation and factors related to androgen excess. Women with PCOS have a higher risk of insulin resistance, hyperinsulinemia, glucose intolerance, dyslipidemia, and an increased prothrombotic state, resulting in a higher risk of type 2 diabetes mellitus, subclinical atherosclerosis, vascular dysfunction, and apparently cardiovascular disease and mortality. The aim of the present article was to summarize current knowledge with focus on a suggestion to the clinical approach and handling of these metabolic risk factors.

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