Home > Journals > Minerva Ginecologica > Past Issues > Minerva Ginecologica 2006 December;58(6) > Minerva Ginecologica 2006 December;58(6):511-26

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

REVIEWS   

Minerva Ginecologica 2006 December;58(6):511-26

Copyright © 2006 EDIZIONI MINERVA MEDICA

language: English

Endometrial stem/progenitor cells and proliferative disorders of the endometrium

Gargett B. E., Chan R. W. S.

1 Center for Women’s Health Research Monash Institute of Medical Research Melbourne, Australia 2 Department of Obstetrics and Gynecology Monash Medical Center Monash University, Clayton, Victoria, Australia


PDF


The human endometrium undergoes cyclical processes of regeneration, differentiation and shedding as part of the menstrual cycle. In non-menstruating species, there are cycles of endometrial growth and apoptosis rather than physical shedding. It was hypothesized many years ago that endometrial stem cells are responsible for the remarkable regenerative capacity of endometrium. In this review, we summarize the first data providing evidence for the presence of adult stem/progenitor cells in human and mouse endometrium using functional assays. This is because adult stem cells are defined by their functional properties rather than by marker expression, and there are no known markers of endometrial stem/progenitor cells. Evidence will be presented which demonstrates that the endometrium contains rare populations of both and epithelial and stromal stem/progenitor cells. These fundamental studies on endometrial stem/progenitor cells will provide new insights into the pathophysiology of various gynecological disorders associated with abnormal endometrial proliferation, including endometriosis, endometrial cancer, endometrial hyperplasia, and adenomyosis. The possible use of endometrial stem/progenitor cells in tissue engineering applications relevant to urogynecology will also be mentioned.

top of page