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Minerva Ginecologica 2002 February;54(1):9-14

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: Italian

Genetic mutations, acquired disorders and obstetric pathology. Personal experience

Arcadia P., Cosco A. G., Ierullo A. M., Palomba S., Guarany R., Muleo G., Santoro R., Zullo F.


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Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems.
Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B).
Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A.
Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.

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