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Minerva Endocrinology 2021 May 20

DOI: 10.23736/S2724-6507.21.03527-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Bone quality in hypoparathyroidism

Donovan TAY 1, Gaia TABACCO 2, John P. BILEZIKIAN 3

1 Department of General Medicine, Sengkang General Hospital, Singhealth, Singapore; 2 Endocrinology and Diabetes Unit, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy; 3 Department of Medicine, Division of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA


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Hypoparathyroidism is a rare disorder characterized by hypocalcemia and deficient or absent levels of parathyroid hormone. The consequences of chronic hypoparathyroidism involve classic target organs of parathyroid hormone, namely the skeleton and the kidneys. In this article, we focus on the abnormalities in bone quality that are associated with hypoparathyroidism. As assessed by a number of modalities, bone quality is compromised. The evidence for abnormal bone quality includes findings from bone histomorphometry, bone material properties, and high-resolution peripheral computed tomography. These abnormalities include low bone turnover, altered skeletal microarchitecture and bone material properties. How these abnormalities relate to fracture risk are under investigation. In this article, we also review the therapeutic effects of parathyroid hormone as replacement therapy in this disease.


KEY WORDS: Bone quality; Hypoparathyroidism; Bone histomorphometry; High-resolution peripheral computed tomography; Parathyroid hormone

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