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Minerva Endocrinology 2021 Apr 15

DOI: 10.23736/S2724-6507.21.03424-6


language: English

Relationship between plasma 12,13-diHOME level and nonalcoholic fatty liver disease in patients with type 2 diabetes and obesity

Sichao WANG 1, 2, Weixia SUN 1, Yiping CHENG 1, Lei WANG 1, Shizhan MA 1, Fei JING 1, Xiujuan ZHANG 1, Xinli ZHOU 1

1 Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China; 2 Department of Infectious Diseases and Hepatology, The Second Hospital of Shandong University, Jinan, China


OBJECTIVE: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal of this study was to investigate whether the 12,13-diHOME was associated with related metabolic markers of nonalcoholic fatty liver disease (NAFLD) in a Chinese population with type 2 diabetes (T2DM) and obesity.
METHODS: This cross-sectional study enrolled 202 subjects with T2DM. Anthropometric parameters, 12,13-diHOME, serum lipids levels, fasting blood-glucose (FBG), serum glycosylated hemoglobin (HbA1c), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), liver and kidney function parameters were collected. NAFLD was diagnosed based on abdominal ultrasonography examination results. A computer-aided ultrasound quantitative method was applied to evaluate the liver fat content (LFC).
RESULTS: The number of the patients with fatty liver was 139 (68.81%) and those with non-fatty liver was 63 (31.19%). Subjects with NAFLD had a higher body mass index (BMI), diastolic blood pressure, serum alanine aminotransferase (ALT), triglyceride (TG), HOMA-IR, LFC, p<0.05 for all. But no significant difference was found in plasma 12,13-diHOME level (p=0.967), though its level trend was higher in non-NAFLD group. Plasma 12,13-diHOME was positively correlated with aspartate aminotransferase (AST), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), blood urea nitrogen (BUN), free fatty acid (FFA), C-peptide, FINS and HOMAIR. It was negatively correlated with height, body weight, glomerular filtration rate (eGFR) and HbA1c.
CONCLUSIONS: Although 12,13-diHOME was correlated with AST, TC, HDL-C, BUN, FFA, C-peptide, FINS, HOMA-IR, eGFR and HbA1c, there was no significant difference in 12,13-diHOME level between the two groups. However, more research should be carried on about this newly found lipokine.

KEY WORDS: NAFLD; T2DM;12,13-diHOME; LFC; Quantitative ultrasound

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