Minerva Endocrinologica 2021 Jan 12

DOI: 10.23736/S0391-1977.20.03217-4

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

The level of the neudesin in Type-2 Diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness

Ovgu KARATAS ¹ ✉, Mehmet CALAN ², Arif YUKSEL ³, Roukie CHOUSEIN ⁴, Giray BOZKAYA ⁵, Murat KARATAS ⁶, Adam USLU ⁶, Erhan TATAR ⁷

¹ Department of Intensive Care, Ege University Faculty of Medicine, Izmir, Turkey; ² Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey;
³ Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey; ⁴ Department of Radiology, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey; ⁵ Department of Biochemistry, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey; ⁶ Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey; ⁶ Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey; ⁷ Department of Nephrology, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey

BACKGROUND: Neudesin is a protein that is secreted from adipose tissue and central nervous system and has a regulatory function on energy metabolism. Although the effect of this protein is shown in the experimental model of type-2 diabetes mellitus (Type-2DM), its effect in humans is not clearly known. In this study, we aimed to evaluate the relationship between serum neudesin level and metabolic, anthropometric and cardiovascular parameters in newly diagnosed Type-2 DM patients (Group 1).
METHODS: Forty patients in each were included in our study for Group 1 and for the control group (Group 2), which consisted of age and sex-matched healthy subjects. Serum neudesin, hs-CRP, carotid intima media thickness (CIMT), body mass index (BMI) and insulin resistance (HOMA-IR) levels were compared prospectively.
RESULTS: Serum neudesin levels were significantly higher in diabetic patients than in the control group (Type 2 DM = 64.69 ± 3.06 ng / ml, Control = 55.52 ± 5.48 ng / ml, P = 0.004 *). There was an independent relationship between serum neudesin and HOMA-IR and BMI. Although there is a correlation between serum neudesin and CIMT ; this feature disappeared in the regression analysis.
CONCLUSIONS: Serum neudesin increased in new diagnosis Type-2 DM patients. This increase seems to be related to obesity and insulin resistance. However, more extensive research is needed to clarify this issue.

KEY WORDS: Type2 Diabetes mellitus; Neudesin; Carotid intima media thickness; hsCRP; HOMA-IR