Home > Journals > Minerva Endocrinology > Past Issues > Minerva Endocrinology 2022 September;47(3) > Minerva Endocrinology 2022 September;47(3):358-70



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Minerva Endocrinology 2022 September;47(3):358-70

DOI: 10.23736/S2724-6507.21.03224-7


language: English

Obesity in childhood: how to improve male adolescence incoming

Paola GUALTIERI 1 , Maria G. TARSITANO 2, Gemma L. DE SANTIS 3, Lorenzo ROMANO 3, Ernesto ESPOSITO 4, Antonino DE LORENZO 1

1 Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy; 2 Department of Experimental Medicine, Sapienza University, Rome, Italy; 3 School of Specialization in Food Science, Tor Vergata University, Rome, Italy; 4 Department of Human Policies, Potenza, Italy

Earlier or delayed puberty can be determined by numerous causes, but the exact mechanisms are not fully known. Anyway, those may be independent from the hypothalamic-pituitary-gonadal axis involvement. Certainly, obesity is one of the main factors. In fact, obesity and infertility are strongly linked. For this reason, we want to analyse the relationship between puberty and obesity and give an updated state-of-the-art starting by discussing a 14-year-old obese boy’s clinical case. Literature data are conflicting. Main criticisms are related to study design and evaluation criteria. Indeed, examined populations are not homogeneous by age, Tanner stage and BMI classification. The obesity epidemic is involved in earlier puberty, and puberty seems to be anticipated in all BMI groups. Very few studies evaluate the level of adiposity in the diagnosis of obesity. However, the role of the adipose tissue is crucial for hormone synthesis and regulation. Therefore, fat mass age-related and not simply BMI has to be considered by clinicians for appropriate diagnosis. Regarding the clinical case, in three months our patient recovered delayed pubertal development following an anti-inflammatory and antioxidant Mediterranean Diet. Loss of weight, as in decrease of fat mass but saving of lean mass, increased testicular volume and testosterone levels occurred. Puberty depends on several factors, including obesity. Further studies are needed to evaluate age groups, Tanner stage, diet and lifestyle, ethnicity and above all the fat/lean mass ratio. Lack of adequate tools could hinder a clinician’s ability to recognize when or if therapeutic intervention is needed.

KEY WORDS: Testis; Dietary supplements; Body Mass Index; Obesity; Hypogonadism

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