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ORIGINAL ARTICLE
Minerva Endocrinology 2022 June;47(2):172-80
DOI: 10.23736/S2724-6507.20.03346-5
Copyright © 2020 EDIZIONI MINERVA MEDICA
language: English
The role of heart rate variability and heart rate turbulence in diabetic retinopathy
Zafer ALAN YALIM 1 ✉, Sümeyra YALIM 2, Özgür EROĞUL 3, Mehmet Cem SABANER 3, Mustafa DOĞAN 3
1 Department of Cardiology, Faculty of Medicine, Health Sciences University of Afyonkarahisar, Afyonkarahisar, Turkey; 2 Department of Internal Medicine, State Hospital of Afyonkarahisar, Afyonkarahisar, Turkey; 3 Department of Ophthalmology, Health Sciences University Hospital of Afyonkarahisar, Afyonkarahisar, Turkey
BACKGROUND: The aim of this study was to evaluate the cardiac autonomic functions of individuals with asymptomatic diabetic retinopathy (DR) and no obvious heart disease by heart rate turbulence (HRT) and heart rate variability (HRV) analysis.
METHODS: A total of 72 patients with type 2 diabetes mellitus: 20 non-retinopathic (NRDM), 26 non-proliferative retinopathic patients (NPDR) and 26 proliferative retinopathic patients (PDR) were enrolled in this cross-sectional study.
RESULTS: The HRV parameters of Standard deviation of NN intervals (SDNN) (119.8±11.7, 101.1±20.2, 100.6±17.04), standard deviation of the average NN intervals (108.3±10.8, 91.2±17.5, 93.6±18.4), SDNN Index (49.5±5.1, 40.1±13.4, 38.6±12.7), Root mean square of successive RR interval differences (28.3±5.1, 22.3±7.5, 26±9.2) and Triangular index (34.4±4.3, 29.7±8.8, 27.3±6.7) were significantly lower in the NPDR and PDR groups than in the NRDM group (for all P<0.05). Also, there was a statistically significant higher Turbulence Onset (-1.80±0.7, -1.1±0.9, -0.43±0.81) and lower Turbulence Slope (8.05±2.59, 5.82±3.39, 4.53±2.07) in HRT parameters in patients in the NPDR and PDR groups than in the NRDM group (P<0.001).
CONCLUSIONS: We found that HRV and HRT parameters had a significant deterioration in retinopathic individuals compared to the group without retinopathy. We think that HRV and HRT analysis can have an important role in the evaluation of these patients.
KEY WORDS: Diabetic retinopathy; Arrhythmias, cardiac; Heart rate