Home > Journals > Minerva Endocrinology > Past Issues > Minerva Endocrinology 2021 June;46(2) > Minerva Endocrinology 2021 June;46(2):226-32

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

ORIGINAL ARTICLE   

Minerva Endocrinology 2021 June;46(2):226-32

DOI: 10.23736/S2724-6507.20.03196-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Elevated urinary IL-36α and IL-18 levels are associated with diabetic nephropathy in patients with type 2 diabetes mellitus

Rohan CHAKRABORTY 1, Rizwana PARVEEN 1, Prabhat VARSHNEY 1, Prem KAPUR 2, Saima KHATOON 3, Nilanjan SAHA 1, Nidhi B. AGARWAL 1

1 School of Chemical and Life Sciences, Center for Translational and Clinical Research, Jamia Hamdard, New Delhi, India; 2 Department of Medicine, HIMSR and HAHC Hospital, Jamia Hamdard, New Delhi, India; 3 Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India



BACKGROUND: Inflammatory cytokines have been reported to be pathogenic factors for the development and progression of diabetic nephropathy (DN). Interleukin (IL)-36α is a newly discovered member of the IL-1 cytokine family that has been implicated in animal models of renal impairment. However, little is known about the role of IL-36α in DN in humans. The purpose of the present study was to assess the levels of IL-36α and IL-18 in type 2 diabetic patients (T2DM) patients with and without DN.
METHODS: Subjects were divided into 3 groups: Control (N.=20), T2DM without DN (N.=30), and T2DM with DN (N.=30). Urinary IL-36α and IL-18 levels were assessed using ELISA. Correlation analysis was performed to determine the association of the IL levels with clinical markers of T2DM and DN.
RESULTS: IL-36α and IL-18 levels were significantly elevated in T2DM patients with DN, when compared to T2DM patients without DN (P<0.0001, P=0.0025, respectively) and controls (P<0.0001, for both). IL-36α levels showed a positive correlation with urinary albumin excretion (r=0.754, P<0.0001), HbA1c (r=0.433, P=0.0168), fasting plasma glucose (r=0.433, P=0.0168) and negative correlation with glomerular filtration rate (r=-0.852 P<0.0001).
CONCLUSIONS: The results highlighted the association of IL-36α with DN. However, further extensive studies are suggested for evaluating the association.


KEY WORDS: Diabetic nephropathies; Albuminuria; Glomerular filtration rate

top of page