Home > Journals > Minerva Endocrinology > Past Issues > Minerva Endocrinologica 2010 December;35(4) > Minerva Endocrinologica 2010 December;35(4):195-209

CURRENT ISSUE
 

JOURNAL TOOLS

Publishing options
eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions
Share

 

REVIEWS  OVARY AND BEYOND 

Minerva Endocrinologica 2010 December;35(4):195-209

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Genetics of premature ovarian failure

Meczekalski B., Podfigurna-Stopa A.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland


PDF


Premature ovarian failure (POF) is defined as a primary ovarian insufficiency before the age of 40 years. It is characterized by a cessation of menstruation for at least 4 months associated with the elevation of serum follicle-stimulating hormone (FSH) concentration (FSH>40 IU/L). It affects approximately 1% of women under 40. Known causes of premature ovarian failure can be classified as genetic, autoimmune, environmental, iatrogenic (after chemotherapy, radiations, surgery) and idiopathic. It is estimated that up to 40% of POF can be attributed to genetic causes. Classification of genetic causes can be different. We present here review of genetic causes of POF based on classification : non-syndromic POF and syndromic causes of POF. The list of the candidate genes related to POF is still increasing. Elucidation of genetic determination of POF has a critical significance for identification the possible marker of POF or possible new kind of POF therapy.

top of page