PANCREATIC CANCER 

Minerva Endocrinologica 2010 March;35(1):27-33

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Molecular therapy of pancreatic cancer

Plentz R. R., Manns M. P., Greten T. F. ✉

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of mortality and morbidity. The 5-year survival rate remains less than 5% and in contrast to other solid tumors, survial has changed only little in the last decade. Overall PDAC treatment shows only limited response to conventional chemotherapeutic agents. Several trials on therapy are ongoing and new targeted agents are in development to improve the treatment outcome of this deadly disease. However, our review presents the current developments of molecular therapies, supports the translational PDAC research and encourage you to take part in further clinical studies.