GROWTH HORMONE: PHYSIOPATHOLOGY 

Minerva Endocrinologica 2002 December;27(4):231-42

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

Growth hormone regulated gene expression

Schwartz J., Huo J. S., Piwien-Pilipuk G.

Growth hormone (GH) regulated gene expression contributes to many of the effects of GH on cellular metabolism, growth and differentiation. Study of model systems has revealed several mechanisms by which GH regulates gene expression. Regulation of expression of the proto-oncogene c-fos involves STAT-, MAPK, and PI-3K-mediated changes in transcripton factors. STAT 5 plays important roles in regulation of spi 2.1 expression and in the sexually dimorphic expression of some liver genes. GH-regulated STAT 5 has also been implicated in regulation of other physiologically important genes, including those encoding components of the IGF-I axis and insulin. Together, these studies provide insight into GH signaling mechanisms and diverse physiological roles of GH.