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Minerva Endocrinologica 2020 Aug 03

DOI: 10.23736/S0391-1977.20.03176-4

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Subclinical hypothyroidism

Jessica CHBAT 1, Shereen EZZAT 1, Giampaolo PAPI 2

1 Endocrine Oncology Site Group, Princess Margaret Cancer Centre, Toronto, Canada; 2 Endocrinology Unit-Northern Area, Azienda USL Modena, Modena, Italy


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Subclinical hypothyroidism - i.e., a condition characterized by serum TSH concentrations above the normal reference range in the presence of normal serum T4 levels - affects 4 to 20% of the population living in iodine-sufficient areas. The present work reviews the clinical challenges regarding, on the one hand, the signs and symptoms possibly related to subclinical hypothyroidism, and on the other hand, the most recent guideline recommendations to treatment.


KEY WORDS: Hypothyroidism; Subclinical thyroid disease; Diagnosis; Therapy

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