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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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Minerva Endocrinologica 2018 Feb 13

DOI: 10.23736/S0391-1977.18.02740-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Role of thyroid ultrasound combined with thyroglobulin in the diagnosis of postoperative recurrence of thyroid cancer

Li ZHANG 1, Guilan ZOU 2

1 Department of Ultrasonography, Ningbo Fenghua People's Hospital, Ningbo, China; 2 Department of Ultrasonography, Lihuili East Hospital, Ningbo Medical Center, Ningbo, China


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BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice.
METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed. At 1 week after 131 I treatment, the systemic single photon emission computed tomography (SPECT) was performed. Finally, the application values of serum Tg, TgAb and ultrasound in the diagnosis of postoperative recurrence of thyroid cancer were analyzed.
RESULTS: The sensitivity, specificity and accuracy of Tg level in detecting of recurrence and metastasis of differentiated thyroid cancer were 78.5%, 73.3% and 77.5%, respectively, and it was difficult to show whether the postoperative recurrence and metastasis of thyroid cancer occurred through the expression level of serum TgAb. Moreover, TgAb in different concentrations had an effect on the diagnosis of metastasis of differentiated thyroid cancer via Tg. When the TgAb level ≥100 IU/mL, the sensitivity, specificity and accuracy of Tg diagnosis were 51.9%, 50.0% and 51.7%, respectively. When the TgAb level <100 IU/mL, the sensitivity, specificity and accuracy of Tg diagnosis were 94.6%, 71.4% and 88.2%, respectively. Besides, the sensitivity, specificity and accuracy of ultrasonic diagnosis of lymphatic metastasis after the treatment of differentiated thyroid cancer were 78.5%, 60.0% and 75.0%, respectively. The sensitivity, specificity and accuracy of ultrasound combined with Tg in the diagnosis of thyroid cancer were 97.4%, 75.0% and 93.6%, respectively. The difference in the metastasis rate of thyroid cancer was not statistically significant between patients with papillary carcinoma and patients with follicular carcinoma after treatment (P>0.05).
CONCLUSIONS: Thyroid ultrasound combined with Tg is of high clinical value in the diagnosis of postoperative recurrence of thyroid cancer, which can significantly improve the sensitivity, specificity and accuracy of clinical diagnosis. The TgAb level can be detected when Tg is used to monitor the postoperative recurrence and metastasis of thyroid cancer, providing a reference for the clinical prevention and treatment.


KEY WORDS: Thyroid ultrasound - Thyroglobulin - Thyroid cancer - Recurrence - Diagnosis

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Publication History

Article first published online: February 13, 21018
Manuscript accepted: January 17, 2018
Manuscript received: September 13, 2017

Cite this article as

Zhang L, Zou G. Role of thyroid ultrasound combined with thyroglobulin in the diagnosis of postoperative recurrence of thyroid cancer. Minerva Endocrinol 2018 Feb 13. DOI: 10.23736/S0391-1977.18.02740-2

Corresponding author e-mail

broueh98@163.com