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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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Minerva Endocrinologica 2018 Feb 13

DOI: 10.23736/S0391-1977.18.02725-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis

Toshiki NAGASAKI 1 , Yuki NAGATA 1, Yosuke WAKITA 1, Shinsuke YAMADA 1, Hitoshi GOTO 1, Yasuo IMANISHI 1, Naoyoshi ONODA 2, Masanori EMOTO 1, Masaaki INABA 1

1 Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine, Osaka City, Japan; 2 Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, Osaka City, Japan


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PURPOSE: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity.
METHODS: Fifty three consecutive RA patients were prospectively separated into two groups on the basis of the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, heterogeneity index (HI) was determined ultrasonographically.
RESULTS: While the male/female ratio, TSH and HI were significantly higher in those with HT than in those without (5/13vs.7/28, p=0.047, mean±SE; 7.25±0.69 vs.2.52±0.30mIU/l, p<0.001; 3.8±0.2 vs.3.2±0.2%, p=0.042, respectively), no differences existed in MMP-3. In those with HT, MMP-3 correlated negatively with FT3 (rho=-0.545, p=0.048) and positively with TPO-Ab and HI (rho=0.735, p=0.02; rho=0.769, p=0.01, respectively). Among them, HI was a significant factor associated positively with MMP-3 (r=0.883, F=31.91).
CONCLUSIONS: The present study demonstrated significant increases of HI and an association between HI and MMP-3 in RA patients with HT. These findings suggest that the inflammation and destruction of the thyroid gland might be closely related to the current activity and terminal joint destruction of RA.


KEY WORDS: Hashimoto's thyroiditis - Rheumatoid arthritis - Matrix metalloproteinase-3 - Anti-thyroid peroxidase antibodies - Anti-thyroid antibodies

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Publication History

Article first published online: February 13, 2018
Manuscript accepted: January 30, 2018
Manuscript received: August 15, 2017

Cite this article as

Nagasaki T, Nagata Y, Wakita Y, Yamada S, Goto H, Imanishi Y, et al. Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis. Minerva Endocrinol 2018 Feb 13. DOI: 10.23736/S0391-1977.18.02725-6

Corresponding author e-mail

toshi-n@jg7.so-net.ne.jp